Characterisation of the novel uORF in enteroviruses

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We have recently reported that enteroviruses encode an additional protein UP in an upstream open reading frame (Lulla et al., Nature Microbiol, 2019). This project focuses on UP expression mechanism and its role in virus release in gut epithelial cells.

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Characterisation of astrovirus replication and pathogenicity

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This project focuses on understanding the formation of the astrovirus replication complex, RNA synthesis mechanisms, proteolytic processing, gut-specific determinants, and the molecular mechanisms responsible for neurovirulence.